Less shocking antitumor agents?
نویسندگان
چکیده
منابع مشابه
ivo Antitumor Activity with Less Neurotoxicity
ownload H-indol-2-yl)phenyl)(3,4,5-trimethoxyphenyl)methanone (I-387) is a novel synthetic compound that ts tubulin action and exhibits potent antitumor activity in various preclinical models. I-387 inhibited vitro growth of several human cancer cell lines with IC50 values in the range of 15 to 39 nmol/L. olar concentrations of the compound induced apoptosis and caused phosphorylation of the an...
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Sudden cardiac death remains the single most frequent cause of mortality in the industrialized world [1]. Indeed, approximately every 100 s somebody dies suddenly in the United States alone [2]. Most frequently, ventricular fibrillation (VF) associated with acute myocardial ischemia or infarction is the cause of circulatory collapse [1]. When untreated, VF is lethal within minutes because the a...
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Vari ous pl'ant preparati ons have been recommended for treatment of warts, tumors and cancerQus growths throughout recorded history. In a classic survey of the available literature, Hartwel1 1 identified over 3,000 plants reported to be of us~ in the treatment of these maladies. Numerous plant extracts have been subjected to detailed testing and fractionation studies in recent years and a wide...
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The bud is all in the timing new study by Schenkman et al. on page 829 reveals that the subcellular localization of yeast budding proteins can be determined by the time the genes are expressed. The genes BUD8 and BUD9 are required for establishment of the bipolar budding pattern in normal diploid cells, in which both poles are specified as potential bud sites. Although the two proteins are simi...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 1999
ISSN: 1087-0156,1546-1696
DOI: 10.1038/5174